Translational control of gene expression via interacting feedback loops
Biological Physics
2019-12-04 v1
Abstract
Translation is a key step in the synthesis of proteins. Accordingly, cells have evolved an intricate array of control mechanisms to regulate this process. By constructing a multi-component mathematical framework for translation we uncover how translation may be controlled via interacting feedback loops. Our results reveal that this interplay gives rise to a remarkable range of protein synthesis dynamics, including oscillations, step-change and bistability. This suggests that cells may have recourse to a much richer set of control mechanisms than was previously understood.
Cite
@article{arxiv.1904.03064,
title = {Translational control of gene expression via interacting feedback loops},
author = {Liang Wang and M. Carmen Romano and Fordyce A. Davidson},
journal= {arXiv preprint arXiv:1904.03064},
year = {2019}
}
Comments
Supplementary Material Available on Request