Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal transition (EMT) plays a critical role. There is extensive cross-talk between metabolism and EMT, but how this leads to coordinated physiological changes is still uncertain. The elusive connection between metabolism and EMT compromises the efficacy of metabolic therapies targeting metastasis. In this review, we aim for clarifying causation between metabolism and EMT based on recent experimental studies and propose integrated theoretical-experimental efforts to better understand the coupled decision-making of metabolism and EMT.
@article{arxiv.2011.13554,
title = {Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer},
author = {Dongya Jia and Jun Hyoung Park and Harsimran Kaur and Kwang Hwa Jung and Sukjin Yang and Shubham Tripathi and Madeline Galbraith and Youyuan Deng and Mohit Kumar Jolly and Benny Abraham Kaipparettu and Jose N. Onuchic and Herbert Levine},
journal= {arXiv preprint arXiv:2011.13554},
year = {2020}
}