Tomographic Phase Imaging with Randomized Probe Imaging

We demonstrate tomographic phase imaging of cubic gold nanoparticles with sub-100 nm resolution requiring just a single far-field coherent diffraction pattern per projection. By using randomized probe imaging (RPI), a real-space amplitude and phase image can be reconstructed from a single diffraction pattern. These phase images are then fed into a standard tomographic workflow to retrieve the 3D volume. Nanoscale X-ray phase tomography has often relied on ptychography, which requires slow 2D scanning for each projection. By using RPI, the data collection is greatly sped up at the cost of some resolution. We compare an RPI-tomography volume to a ptychography-tomography volume of the same sample, finding high consistency between the two methods. To the best of our knowledge, this is the first application of RPI to tomography.