Time and length scales of autocrine signals in three dimensions
Quantitative Methods
2009-11-13 v1 Subcellular Processes
Abstract
A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.
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Cite
@article{arxiv.0709.3602,
title = {Time and length scales of autocrine signals in three dimensions},
author = {Mathieu Coppey and Alexander M. Berezhkovskii and Stuart C. Sealfon and Stanislav Y. Shvartsman},
journal= {arXiv preprint arXiv:0709.3602},
year = {2009}
}
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15 pages