This paper reports nano-CT analysis of brain tissues of schizophrenia and control cases. The analysis revealed that: (1) neuronal structures vary between individuals, (2) the mean curvature of distal neurites of the schizophrenia cases was 1.5 times higher than that of the controls, and (3) dendritic spines were categorized into two geometrically distinctive groups, though no structural differences were observed between the disease and control cases. The differences in the neurite curvature result in differences in the spatial trajectory and hence alter neuronal circuits. We suggest that the structural alteration of neurons in the schizophrenia cases should reflect psychiatric symptoms of schizophrenia.
@article{arxiv.1804.00404,
title = {Three-dimensional alteration of neurites in schizophrenia},
author = {Ryuta Mizutani and Rino Saiga and Akihisa Takeuchi and Kentaro Uesugi and Yasuko Terada and Yoshio Suzuki and Vincent De Andrade and Francesco De Carlo and Susumu Takekoshi and Chie Inomoto and Naoya Nakamura and Itaru Kushima and Shuji Iritani and Norio Ozaki and Soichiro Ide and Kazutaka Ikeda and Kenichi Oshima and Masanari Itokawa and Makoto Arai},
journal= {arXiv preprint arXiv:1804.00404},
year = {2019}
}
Comments
24 pages, 4 figures, and 1 table. Supplementary materials are available from DOI link