Thermodynamics of G.A mispairs in DNA: continuum electrostatic model
Biological Physics
2010-08-13 v1 Chemical Physics
Abstract
An analysis of the stability of a duplex containing G.A mispairs or G.A/A.G tandem during DNA melting has revealed that duplex stability depends on both DNA sequences and on the conformations of the G.A mispairs. The thermodynamics of single pair opening for G(anti).A(syn) and G(anti).A(anti) conformations adopted by G.A mispairs is found to strongly correlate with that of the canonical base pairs, while for sheared conformation a significant difference is observed.
Keywords
Cite
@article{arxiv.0807.1712,
title = {Thermodynamics of G.A mispairs in DNA: continuum electrostatic model},
author = {Julia Berashevich and Tapash Chakraborty},
journal= {arXiv preprint arXiv:0807.1712},
year = {2010}
}