Phenotype switching can be triggered by external stimuli and by intrinsic stochasticity. Here, we focus on the motility-matrix production switch in Bacillus subtilis. We use modeling to describe the SinR-SlrR bistable switch its regulation by SinI, and to distinguish different sources of stochasticity. Our simulations indicate that intrinsic fluctuations in the synthesis of SinI are insufficient to drive spontaneous switching and suggest that switching is triggered by upstream noise from the Spo0A phosphorelay.
Cite
@article{arxiv.2308.12780,
title = {The motility-matrix production switch in Bacillus subtilis -- a modeling perspective},
author = {Simon Dannenberg and Jonas Penning and Alexander Simm and Stefan Klumpp},
journal= {arXiv preprint arXiv:2308.12780},
year = {2023}
}