CUORE is the first ton-scale experiment based on the bolometric technique to search for neutrinoless double-beta decay. Its core is made of 988 TeO2 crystals cooled down to 10mK. The temperature must be as stable as possible during detector operations, for an integrated live-time of about 5 years. To reach these goals, a dedicated cryogenic system has been developed. Temperature stabilization of the crystals response will be performed to compensate for residual instabilities. External vibrations that can deteriorate the crystals energy resolution, are dumped thanks to a suspension system. Moreover, a thorough selection and cleaning process performed on the construction material will allow the abatement of the radioactive backgrounds. Here the key aspects of the systems are presented.