StudyU: a platform for designing and conducting innovative digital N-of-1 trials
Abstract
N-of-1 trials are the gold standard study design to evaluate individual treatment effects and derive personalized treatment strategies. Digital tools have the potential to initiate a new era of N-of-1 trials in terms of scale and scope, but fully-functional platforms are not yet available. Here, we present the open source StudyU platform which includes the StudyU designer and StudyU app. With the StudyU designer, scientists are given a collaborative web application to digitally specify, publish, and conduct N-of-1 trials. The StudyU app is a smartphone application with innovative user-centric elements for participants to partake in the published trials and assess the effects of different interventions on their health. Thereby, the StudyU platform allows clinicians and researchers worldwide to easily design and conduct digital N-of-1 trials in a safe manner. We envision that StudyU can change the landscape of personalized treatments both for patients and healthy individuals, democratize and personalize evidence generation for self-optimization and medicine, and can be integrated in clinical practice.
Keywords
Cite
@article{arxiv.2012.14201,
title = {StudyU: a platform for designing and conducting innovative digital N-of-1 trials},
author = {Stefan Konigorski and Sarah Wernicke and Tamara Slosarek and Alexander M. Zenner and Nils Strelow and Ferenc D. Ruether and Florian Henschel and Manisha Manaswini and Fabian Pottbäcker and Jonathan A. Edelman and Babajide Owoyele and Matteo Danieletto and Eddye Golden and Micol Zweig and Girish Nadkarni and Erwin Böttinger},
journal= {arXiv preprint arXiv:2012.14201},
year = {2021}
}
Comments
Manuscript: 14 pages, 5 figures. Supplements: 23 pages, Supplementary Text 1-5, Supplementary Figures 1-5