The characterization of protein-nanoparticle assemblies in solution remains a challenge. We demonstrate a technique based on a graphene microelectrode for structural-functional analysis of model systems composed of nanoparticles enclosed in open-pore and closed-pore ferritin molecules. The method readily resolves the difference in accessibility of the enclosed nanoparticle for charge transfer and offers the prospect for quantitative analysis of pore-mediated transport shed light on the spatial orientation of the protein subunits on the nanoparticle surface, faster and with higher sensitivity than conventional catalysis methods.
@article{arxiv.1708.08970,
title = {Structural-Functional Analysis of Engineered Protein-Nanoparticle Assemblies Using Graphene Microelectrodes},
author = {Jinglei Ping and Katherine W. Pulsipher and Ramya Vishnubhotla and Jose A. Villegas and Tacey L. Hicks and Stephanie Honig and Jeffery G. Saven and Ivan J. Dmochowski and A. T. Charlie Johnson},
journal= {arXiv preprint arXiv:1708.08970},
year = {2017}
}