Spheroidal and Nanocrystal Structures From Carbodiimide Crosslinking Reaction With RADA16

Jorge Monreal; Robert Hyde

Spheroidal and Nanocrystal Structures From Carbodiimide Crosslinking Reaction With RADA16

Soft Condensed Matter 2016-08-30 v1

Authors: Jorge Monreal , Robert Hyde

Abstract

RADA16 is a widely studied polypeptide known for its ability to self-assemble into $\beta$ -sheets that form nanofibers. Here we show that it is possible to self-crosslink the molecule via 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) as aqueous solutions. The product results in a mix of nanocrystals and near micron-size spherules. SEM and TEM pictures provide a view of the structures and nano tracking analysis give their size distributions. FTIR analysis provides evidence for the existence of a crosslinking reaction.

Keywords

RADA16 self-assembly carbodiimide crosslinking EDC nanocrystals spheroidal structures beta-sheets

Cite

@article{arxiv.1608.08064,
  title  = {Spheroidal and Nanocrystal Structures From Carbodiimide Crosslinking Reaction With RADA16},
  author = {Jorge Monreal and Robert Hyde},
  journal= {arXiv preprint arXiv:1608.08064},
  year   = {2016}
}

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