Spectral flow, index and the signature operator

We relate the spectral flow to the index for paths of selfadjoint Breuer-Fredholm operators affiliated to a semifinite von Neumann algebra, generalizing results of Robbin-Salamon and Pushnitski. Then we prove the vanishing of the von Neumann spectral flow for the tangential signature operator of a foliated manifold when the metric is varied. We conclude that the tangential signature of a foliated manifold with boundary does not depend on the metric. In the Appendix we reconsider integral formulas for the spectral flow of paths of bounded operators.