We investigate the problem of signal transduction via a descriptive analysis of the spatial organization of the complement of proteins exerting a certain function within a cellular compartment. We propose a scheme to assign a numerical value to individual proteins in a protein interaction network by means of a simple optimization algorithm. We test our procedure against datasets focusing on the proteomes in the neurite and soma compartments.
@article{arxiv.1202.0405,
title = {Spatial organization of proteomes: A low-rank approximation},
author = {Federico Felizzi and Jerome Galtier and Georgios Fengos and Dagmar Iber},
journal= {arXiv preprint arXiv:1202.0405},
year = {2012}
}