Spaces of knotted circles and exotic smooth structures

Suppose that $N_1$ and $N_2$ are closed smooth manifolds of dimension $n$ that are homeomorphic. We prove that the spaces of smooth knots $Emb(S^1, N_1)$ and $Emb(S^1, N_2)$ have the same homotopy $(2n-7)$-type. In the 4-dimensional case this means that the spaces of smooth knots in homeomorphic 4-manifolds have sets $\pi_0$ of components that are in bijection, and the corresponding path components have the same fundamental groups $\pi_1$. The result about $\pi_0$ is well-known and elementary, but the result about $\pi_1$ appears to be new. The result gives a negative partial answer to a question of Oleg Viro. Our proof uses the Goodwillie-Weiss embedding tower. We give a new model for the quadratic stage of the Goodwillie-Weiss tower, and prove that the homotopy type of the quadratic approximation of the space of knots in $N$ does not depend on the smooth structure on $N$. Our results also give a lower bound on $\pi_2 Emb(S^1, N)$. We use our model to show that for every choice of basepoint, each of the homotopy groups $\pi_1$ and $\pi_2$ of $Emb(S^1, S^1\times S^3)$ contains an infinitely generated free abelian group.