Developing and enforcing study protocols is crucial in medical research, especially as interactions with participants become more intricate. Traditional rules-based systems struggle to provide the automation and flexibility required for real-time, personalized data collection. We introduce SmartState, a state-based system designed to act as a personal agent for each participant, continuously managing and tracking their unique interactions. Unlike traditional reporting systems, SmartState enables real-time, automated data collection with minimal oversight. By integrating large language models to distill conversations into structured data, SmartState reduces errors and safeguards data integrity through built-in protocol and participant auditing. We demonstrate its utility in research trials involving time-dependent participant interactions, addressing the increasing need for reliable automation in complex clinical studies.
@article{arxiv.2305.04411,
title = {SmartState: An Automated Research Protocol Adherence System},
author = {Samuel E. Armstrong and Mitchell A. Klusty and Aaron D. Mullen and Jeffery C. Talbert and V. K. Cody Bumgardner},
journal= {arXiv preprint arXiv:2305.04411},
year = {2025}
}