Simulating Organogenesis in COMSOL: Cell-based Signaling Models
Quantitative Methods
2013-09-26 v1 Tissues and Organs
Abstract
Most models of biological pattern formation are simulated on continuous domains even though cells are discrete objects that provide internal boundaries to the diffusion of regulatory components. In our previous papers on simulating organogenesis in COMSOL (Germann et al COMSOL Conf Procedings 2011; Menshykau and Iber, COMSOL Conf Proceedings 2012) we discussed methods to efficiently solve signaling models on static and growing continuous domains. Here we discuss COMSOL-based methods to study spatio-temporal signaling models at cellular resolution with subcellular compartments, i.e. cell membrane, cytoplasm, and nucleus.
Cite
@article{arxiv.1309.6479,
title = {Simulating Organogenesis in COMSOL: Cell-based Signaling Models},
author = {Jannik Vollmer and Denis Menshykau and Dagmar Iber},
journal= {arXiv preprint arXiv:1309.6479},
year = {2013}
}
Comments
6 pages, 3 Figures, Proceedings of COMSOL Conference 2013