Signal Propagation in Nonlinear Stochastic Gene Regulatory Networks
Abstract
The structure of a stochastic nonlinear gene regulatory network is uncovered by studying its response to input signal generators. Four applications are studied in detail: a nonlinear connection of two linear systems, the design of a logic pulse, a molecular amplifier and the interference of three signal generators in E2F1 regulatory element. The gene interactions are presented using molecular diagrams that have a precise mathematical structure and retain the biological meaning of the processes.
Keywords
Cite
@article{arxiv.q-bio/0510055,
title = {Signal Propagation in Nonlinear Stochastic Gene Regulatory Networks},
author = {Sever Achimescu and Ovidiu Lipan},
journal= {arXiv preprint arXiv:q-bio/0510055},
year = {2007}
}
Comments
45 pages, 14 figures, Excerpts from this manuscript were presented at the 3rd International Conference on Pathways, Networks, and Systems: Theory and Experiments, October 2-7, Rhodes Greece 2005. A reduced version was submitted on May 24th 2005 to IEE Systems Biology. High quality figures at http://www.cbgm.mcg.edu/signal.pdf