Numerical simulations on a 2-dimensional model system showed that voids are induced primarily due to shape anisotropy in binary mixtures of interacting disks. The results of such a simple model account for the key features seen in a variety of flux experiments using liposomes and biological membranes.
@article{arxiv.cond-mat/0002148,
title = {Shape anisotropy and Voids},
author = {Gauri R. Pradhan and Sagar A. Pandit and Anil D. Gangal and V. Sitaramam},
journal= {arXiv preprint arXiv:cond-mat/0002148},
year = {2007}
}