Sequence heterogeneity and the dynamics of molecular motors
Abstract
The effect of sequence heterogeneity on the dynamics of molecular motors is reviewed and analyzed using a set of recently introduced lattice models. First, we review results for the influence of heterogenous tracks such as a single-strand of DNA or RNA on the dynamics of the motors. We stress how the predicted behavior might be observed experimentally in anomalous drift and diffusion of motors over a wide range of parameters near the stall force and discuss the extreme limit of strongly biased motors with one-way hopping. We then consider the dynamics in an environment containing a variety of different fuels which supply chemical energy for the motor motion, either on a heterogeneous or on a periodic track. The results for motion along a periodic track are relevant to kinesin motors in a solution with a mixture of different nucleotide triphosphate fuel sources.
Cite
@article{arxiv.cond-mat/0506797,
title = {Sequence heterogeneity and the dynamics of molecular motors},
author = {Yariv Kafri and David R. Nelson},
journal= {arXiv preprint arXiv:cond-mat/0506797},
year = {2015}
}
Comments
To appear in a JPhys special issue on molecular motors