Reply to Comment on "Criterion that Determines the Foldability of Proteins"
Condensed Matter
2009-10-28 v2 q-bio
Abstract
We point out that the correlation between folding times and in protein-like heteropolymer models where and are the collapse and folding transition temperatures was already established in 1993 before the other presumed equivalent criterion (folding times correlating with alone) was suggested. We argue that the folding times for these models show no useful correlation with the energy gap even if restricted to the ensemble of compact structures as suggested by Karplus and Shakhnovich (cond-mat/9606037).
Cite
@article{arxiv.cond-mat/9607060,
title = {Reply to Comment on "Criterion that Determines the Foldability of Proteins"},
author = {D. K. Klimov and D. Thirumalai},
journal= {arXiv preprint arXiv:cond-mat/9607060},
year = {2009}
}
Comments
6 pages, Latex, 2 Postscript figures. Plots explicitly showing the lack of correlation between folding time and energy gap are added