Reconsidering the significance of genomic word frequency
Genomics
2007-05-23 v1
Abstract
We propose that the distribution of DNA words in genomic sequences can be primarily characterized by a double Pareto-lognormal distribution, which explains lognormal and power-law features found across all known genomes. Such a distribution may be the result of completely random sequence evolution by duplication processes. The parametrization of genomic word frequencies allows for an assessment of significance for frequent or rare sequence motifs.
Keywords
Cite
@article{arxiv.q-bio/0609022,
title = {Reconsidering the significance of genomic word frequency},
author = {Miklós Csűrös and Laurent Noé and Gregory Kucherov},
journal= {arXiv preprint arXiv:q-bio/0609022},
year = {2007}
}