English

Query, Don't Train: Privacy-Preserving Tabular Prediction from EHR Data via SQL Queries

Databases 2025-09-23 v4

Abstract

Electronic health records (EHRs) contain richly structured, longitudinal data essential for predictive modeling, yet stringent privacy regulations (e.g., HIPAA, GDPR) often restrict access to individual-level records. We introduce \textbf{Query, Don't Train} (QDT): a \textbf{structured-data foundation-model interface} enabling \textbf{tabular inference} via LLM-generated SQL over EHRs. Instead of training on or accessing individual-level examples, QDT uses a large language model (LLM) as a schema-aware query planner to generate privacy-compliant SQL queries from a natural language task description and a test-time input. The model then extracts summary-level population statistics through these SQL queries, and the LLM performs chain-of-thought reasoning over the results to make predictions. This inference-time-only approach enables prediction without supervised model training, ensures interpretability through symbolic, auditable queries, naturally handles missing features without imputation or preprocessing, and effectively manages high-dimensional numerical data to enhance analytical capabilities. We validate QDT on the task of 30-day hospital readmission prediction for Type 2 diabetes patients using a MIMIC-style EHR cohort, achieving F1 = 0.70, which outperforms TabPFN (F1 = 0.68). To our knowledge, this is the first demonstration of LLM-driven, privacy-preserving structured prediction using only schema metadata and aggregate statistics -- offering a scalable, interpretable, and regulation-compliant alternative to conventional foundation-model pipelines.

Keywords

Cite

@article{arxiv.2505.21801,
  title  = {Query, Don't Train: Privacy-Preserving Tabular Prediction from EHR Data via SQL Queries},
  author = {Josefa Lia Stoisser and Marc Boubnovski Martell and Kaspar Märtens and Lawrence Phillips and Stephen Michael Town and Rory Donovan-Maiye and Julien Fauqueur},
  journal= {arXiv preprint arXiv:2505.21801},
  year   = {2025}
}
R2 v1 2026-07-01T02:44:46.499Z