Quantum reference frames beyond subsystems: a reconstruction and generalization of the perspective-neutral framework

We generalize the notion of quantum reference frames (QRFs) to cases where the frame does not necessarily correspond to a tensor factor subsystem, but to a covariant quantum instrument. This unlocks a variety of physical applications: "frames of labeling" for indistinguishable particles, suggesting explanations for the symmetrization postulate and the absence of parastatistics, and yielding a transparent description of the entanglement of bosons and fermions; and relational clocks reproducing the Schr\"odinger equation exactly even when all subsystems are interacting or when there are frequency superselection sectors. Our work generalizes the perspective-neutral approach to QRFs pioneered by H\"ohn and co-authors, which we reconstruct from a simple operational scenario. We give a resource-theoretic grounding of this framework, and show how the notion of completely covariant operations explains the relevance of the charge-zero sector and the pure-state transformation behavior across perspectives. This also suggests operational clarifications of some aspects of constraint quantization, e.g. of the meaning of constraint equations such as $C|\psi\rangle=0$. Some of our results, such as our generalization of relationalization maps to instruments, apply more broadly to other QRF frameworks too, and they contribute to bridging the gap between operational quantum information theory and the internal QRF research program.