Pulsatile Drug Delivery System Based on Electrohydrodynamic Method
Abstract
Electrohydrodynamic (EHD) generation, a commonly used method in BioMEMS, plays a significant role in the pulsatile drug delivery system for a decade. In this paper, an EHD based drug delivery system is well designed, which can be used to generate a single drug droplet as small as 2.83 nL in 8.5 ms with a total device of 2\times2\times3 mm^3, and an external supplied voltage of 1500 V. Theoretically, we derive the expressions for the size and the formation time of a droplet generated by EHD method, while taking into account the drug supply rate, properties of liquid, gap between two electrodes, nozzle size, and charged droplet neutralization. This work proves a repeatable, stable and controllable droplet generation and delivery system based on EHD method experimentally as well as theoretically.
Keywords
Cite
@article{arxiv.1207.1844,
title = {Pulsatile Drug Delivery System Based on Electrohydrodynamic Method},
author = {Yi Zheng and Yuan Zhang and Junqiang Hu and Wenle Gao},
journal= {arXiv preprint arXiv:1207.1844},
year = {2012}
}
Comments
7 pages, 10 figures