ProtoMedX: Towards Explainable Multi-Modal Prototype Learning for Bone Health Classification
Abstract
Bone health studies are crucial in medical practice for the early detection and treatment of Osteopenia and Osteoporosis. Clinicians usually make a diagnosis based on densitometry (DEXA scans) and patient history. The applications of AI in this field are ongoing research. Most successful methods rely on deep learning models that use vision alone (DEXA/X-ray imagery) and focus on prediction accuracy, while explainability is often disregarded and left to post hoc assessments of input contributions. We propose ProtoMedX, a multi-modal (multimodal) model that uses both DEXA scans of the lumbar spine and patient records. ProtoMedX's prototype-based architecture is explainable by design, which is crucial for medical applications, especially in the context of the upcoming EU AI Act, as it allows explicit analysis of model decisions, including incorrect ones. ProtoMedX demonstrates state-of-the-art performance in bone health classification while also providing explanations that can be visually understood by clinicians. Using a dataset of 4,160 real NHS patients, the proposed ProtoMedX achieves 87.58% accuracy in vision-only tasks and 89.8% in its multi-modal variant, both surpassing existing published methods.
Cite
@article{arxiv.2509.14830,
title = {ProtoMedX: Towards Explainable Multi-Modal Prototype Learning for Bone Health Classification},
author = {Alvaro Lopez Pellicer and Andre Mariucci and Plamen Angelov and Marwan Bukhari and Jemma G. Kerns},
journal= {arXiv preprint arXiv:2509.14830},
year = {2025}
}
Comments
ICCV 2025 (PHAROS-AFE-AIMI: Adaptation, Fairness, and Explainability in Medical Imaging). 8 pages, 5 figures, 4 tables. Keywords: multi-modal, multimodal, prototype learning, explainable AI, interpretable models, case-based reasoning, medical imaging, DEXA, bone health, osteoporosis, osteopenia, diagnosis, classification, clustering