English

Persistence of Activity in Threshold Contact Processes, an "Annealed Approximation" of Random Boolean Networks

Probability 2009-12-01 v1

Abstract

We consider a model for gene regulatory networks that is a modification of Kauffmann's (1969) random Boolean networks. There are three parameters: n=n = the number of nodes, r=r = the number of inputs to each node, and p=p = the expected fraction of 1's in the Boolean functions at each node. Following a standard practice in the physics literature, we use a threshold contact process on a random graph on nn nodes, in which each node has in degree rr, to approximate its dynamics. We show that if r3r\ge 3 and r2p(1p)>1r \cdot 2p(1-p)>1, then the threshold contact process persists for a long time, which correspond to chaotic behavior of the Boolean network. Unfortunately, we are only able to prove the persistence time is exp(cnb(p))\ge \exp(cn^{b(p)}) with b(p)>0b(p)>0 when r2p(1p)>1r\cdot 2p(1-p)> 1, and b(p)=1b(p)=1 when (r1)2p(1p)>1(r-1)\cdot 2p(1-p)>1.

Keywords

Cite

@article{arxiv.0911.5339,
  title  = {Persistence of Activity in Threshold Contact Processes, an "Annealed Approximation" of Random Boolean Networks},
  author = {Shirshendu Chatterjee and Rick Durrett},
  journal= {arXiv preprint arXiv:0911.5339},
  year   = {2009}
}

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21 pages