Dynamic PET enables the quantitative estimation of physiology-related parameters and is widely utilized in research and increasingly adopted in clinical settings. Parametric imaging in dynamic PET requires kinetic modeling to estimate voxel-wise physiological parameters based on specific kinetic models. However, parametric images estimated through kinetic model fitting often suffer from low image quality due to the inherently ill-posed nature of the fitting process and the limited counts resulting from non-continuous data acquisition across multiple bed positions in whole-body PET. In this work, we proposed a diffusion model-based kinetic modeling framework for parametric image estimation, using the Patlak model as an example. The score function of the diffusion model was pre-trained on static total-body PET images and served as a prior for both Patlak slope and intercept images by leveraging their patch-wise similarity. During inference, the kinetic model was incorporated as a data-consistency constraint to guide the parametric image estimation. The proposed framework was evaluated on total-body dynamic PET datasets with different dose levels, demonstrating the feasibility and promising performance of the proposed framework in improving parametric image quality.
@article{arxiv.2512.19584,
title = {Patlak Parametric Image Estimation from Dynamic PET Using Diffusion Model Prior},
author = {Ziqian Huang and Boxiao Yu and Siqi Li and Savas Ozdemir and Sangjin Bae and Jae Sung Lee and Guobao Wang and Kuang Gong},
journal= {arXiv preprint arXiv:2512.19584},
year = {2025}
}