Domain structure of paracetamol -- popular antipyretic analgesic -- was investigated by infrared (IR) spectroscopy using synchrotron radiation. Absorbance and retardance maps reveal molecular orientation inside the micro-domains of the paracetamol form II which has a better water solubility and compressibility compared to the commercially used forms I. The developed method of analysis representing orientation of optical slow(fast)-axis is compared with azimuthal orientation of the absorbance at several specific IR bands using vector maps. High brightness of synchrotron radiation and hyper-spectral mapping of structural domains in paracetamol clearly reveals the domain boundaries and can potentially be used to observe \emph{in situ} intra-phase transformations of paracetamol forms-I, II, III and melting, which are important for making medical tablets and powders by an industrial process.
Cite
@article{arxiv.1901.00728,
title = {Paracetamol Micro-Structure Analysis by Optical Mapping},
author = {Reo Honda and Meguya Ryu and Armandas Balcytis and Jitraporn Vongsvivut and Mark J. Tobin and Saulius Juodkazis and Junko Morikawa},
journal= {arXiv preprint arXiv:1901.00728},
year = {2019}
}
Comments
eight figures in the main text and one in supplement