Efficient and precise quantification of lymphocytes in histopathology slides is imperative for the characterization of the tumor microenvironment and immunotherapy response insights. We developed a data-centric optimization pipeline that attain great lymphocyte detection performance using an off-the-shelf YOLOv5 model, without any architectural modifications. Our contribution that rely on strategic dataset augmentation strategies, includes novel biological upsampling and custom visual cohesion transformations tailored to the unique properties of tissue imagery, and enables to dramatically improve model performances. Our optimization reveals a pivotal realization: given intensive customization, standard computational pathology models can achieve high-capability biomarker development, without increasing the architectural complexity. We showcase the interest of this approach in the context of breast cancer where our strategies lead to good lymphocyte detection performances, echoing a broadly impactful paradigm shift. Furthermore, our data curation techniques enable crucial histological analysis benchmarks, highlighting improved generalizable potential.
@article{arxiv.2405.13710,
title = {Optimizing Lymphocyte Detection in Breast Cancer Whole Slide Imaging through Data-Centric Strategies},
author = {Amine Marzouki and Zhuxian Guo and Qinghe Zeng and Camille Kurtz and Nicolas Loménie},
journal= {arXiv preprint arXiv:2405.13710},
year = {2024}
}