Optimized free energies from bidirectional single-molecule force spectroscopy
Statistical Mechanics
2008-05-07 v2
Abstract
An optimized method for estimating path-ensemble averages using data from processes driven in opposite directions is presented. Based on this estimator, bidirectional expressions for reconstructing free energies and potentials of mean force from single-molecule force spectroscopy - valid for biasing potentials of arbitrary stiffness - are developed. Numerical simulations on a model potential indicate that these methods perform better than unidirectional strategies.
Keywords
Cite
@article{arxiv.0802.0224,
title = {Optimized free energies from bidirectional single-molecule force spectroscopy},
author = {David D. L. Minh and Artur B. Adib},
journal= {arXiv preprint arXiv:0802.0224},
year = {2008}
}
Comments
4 pages, 2 figures