Optimal length and signal amplification in weakly activated signal transduction cascades
Optimization and Control
2007-05-23 v1 Molecular Networks
Abstract
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the characterization of the final outcome. The most efficient design of a cascade for generating sharp signals, is obtained by choosing all the off rates equal, and a ``universal'' finite optimal length.
Keywords
Cite
@article{arxiv.math/0311357,
title = {Optimal length and signal amplification in weakly activated signal transduction cascades},
author = {Madalena Chaves and Eduardo D. Sontag and Robert J. Dinerstein},
journal= {arXiv preprint arXiv:math/0311357},
year = {2007}
}
Comments
27 pages, 10 figures, LaTeX file