On Segre's bound for fat points in $\mathbb{P}^n$

For a scheme of fat points $Z$ defined by the saturated ideal $\mathcal{I}_Z$, the regularity index computes the Castelnuovo-Mumford regularity of the Cohen-Macaulay ring $R/\mathcal{I}_Z.$ For points in " general position" we improve the bound for the regularity index computed by Segre for $\mathbb {P}^2$ and generalised by Catalisano, Trung and Valla for $\mathbb {P}^n$. Moreover, we prove that the generalised Segre's bound conjectured by Fatabbi and Lorenzini holds for $n+3$ arbitrary points in $\mathbb {P}^n$. We propose a modification of Segre's conjecture for arbitrary points and we discuss some evidences.