English

On Periodic Reference Tracking Using Batch-Mode Reinforcement Learning with Application to Gene Regulatory Network Control

Systems and Control 2013-03-13 v1 Optimization and Control

Abstract

In this paper, we consider the periodic reference tracking problem in the framework of batch-mode reinforcement learning, which studies methods for solving optimal control problems from the sole knowledge of a set of trajectories. In particular, we extend an existing batch-mode reinforcement learning algorithm, known as Fitted Q Iteration, to the periodic reference tracking problem. The presented periodic reference tracking algorithm explicitly exploits a priori knowledge of the future values of the reference trajectory and its periodicity. We discuss the properties of our approach and illustrate it on the problem of reference tracking for a synthetic biology gene regulatory network known as the generalised repressilator. This system can produce decaying but long-lived oscillations, which makes it an interesting system for the tracking problem. In our companion paper we also take a look at the regulation problem of the toggle switch system, where the main goal is to drive the system's states to a specific bounded region in the state space.

Keywords

Cite

@article{arxiv.1303.2987,
  title  = {On Periodic Reference Tracking Using Batch-Mode Reinforcement Learning with Application to Gene Regulatory Network Control},
  author = {Aivar Sootla and Natalja Strelkowa and Damien Ernst and Mauricio Barahona and Guy-Bart Stan},
  journal= {arXiv preprint arXiv:1303.2987},
  year   = {2013}
}
R2 v1 2026-06-21T23:41:02.292Z