Nonthermal Fluctuations of the Mitotic Spindle
Biological Physics
2015-01-21 v2
Abstract
We present direct measurements of fluctuations in the nucleus of yeast cells. While prior work has shown these fluctuations to be active and non-thermal in character, their origin and time dependence are not understood. We show that the nuclear fluctuations we observe are quantitatively consistent with uncorrelated, active force fluctuations driving a nuclear medium that is dominated by an uncondensed DNA solution, for which we perform rheological measurements on an {\it in vitro} model system under similar conditions to what is expected in the nucleus.
Keywords
Cite
@article{arxiv.1312.4213,
title = {Nonthermal Fluctuations of the Mitotic Spindle},
author = {K. Smith and B. Griffin and H. Byrd and F. C. MacKintosh and M. L. Kilfoil},
journal= {arXiv preprint arXiv:1312.4213},
year = {2015}
}