NLCG-Net: A Model-Based Zero-Shot Learning Framework for Undersampled Quantitative MRI Reconstruction

Typical quantitative MRI (qMRI) methods estimate parameter maps in a two-step pipeline that first reconstructs images from undersampled k-space data and then performs model fitting, which is prone to biases and error propagation. We propose NLCG-Net, a model-based nonlinear conjugate gradient (NLCG) framework for joint T2/T1 estimation that incorporates a U-Net regularizer trained in a scan-specific, zero-shot fashion. The method directly estimates qMRI maps from undersampled k-space using mono-exponential signal modeling with scan-specific neural network regularization, enabling high-fidelity T1 and T2 mapping. Experimental results on T2 and T1 mapping demonstrate that NLCG-Net improves estimation quality over subspace reconstruction at high acceleration factors.