New views of old proteins: clarifying the enigmatic proteome
Abstract
All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide provocative projections for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we offer potential futures for a next generation of disruptive approaches to define, quantify and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.
Keywords
Cite
@article{arxiv.2108.07660,
title = {New views of old proteins: clarifying the enigmatic proteome},
author = {Participants in a NIH Workshop on Functional and Integrative Proteomics and : and Kristin E. Burnum Johnson and Thomas P. Conrads and Richard R. Drake and Amy E. Herr and Ravi Iyengar and Ryan T. Kelly and Emma Lundberg and Michael J. MacCoss and Alexandra Naba and Garry P. Nolan and Pavel A. Pevzner and Karin D. Rodland and Salvatore Sechi and Nikolai Slavov and Jeffrey M. Spraggins and Jennifer E. Van Eyk and Marc Vidal and Christine Vogel and David R. Walt and Neil L. Kelleher},
journal= {arXiv preprint arXiv:2108.07660},
year = {2021}
}
Comments
Submitted to Nature. 22 Pages. 6 Figures. Corresponding author Neil L. Kelleher