Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

For the first time in the world behavioral functions of laboratory mammals exposed to silver nanoparticles were studied with the regard to age. Silver nanoparticles coated with polyvinylpyrrolidone with the size of 8.7 nm were used in the present research as a potential xcenobiotic. Elder mice adapted to the xcenobiotic better than younger animals. Younger animals demonstrated more drastic anxiety than the elder ones. Thus, it is concluded that adaptive homeostasis non-linearly changes with the age. Presumably, it may improve during the prime of life and start to decline just after certain stage.