Negative-feedback self-regulation contributes to robust and high-fidelity transmembrane signal transduction
Cell Behavior
2013-04-23 v2 Molecular Networks
Abstract
We present a minimal motif model for transmembrane cell signaling. The model assumes signaling events taking place in spatially distributed nanoclusters regulated by a birth/death dynamics. The combination of these spatio-temporal aspects can be modulated to provide a robust and high-fidelity response behavior without invoking sophisticated modeling of the signaling process as a sequence of cascade reactions and fine-tuned parameters. Our results show that the fact that the distributed signaling events take place in nanoclusters with a finite lifetime regulated by local production is sufficient to obtain a robust and high-fidelity response.
Keywords
Cite
@article{arxiv.1212.4745,
title = {Negative-feedback self-regulation contributes to robust and high-fidelity transmembrane signal transduction},
author = {M. Ángeles Serrano and Manuel Jurado and Ramon Reigada},
journal= {arXiv preprint arXiv:1212.4745},
year = {2013}
}