Necessary and sufficient conditions for identifiability in the admixture model
Abstract
We consider M SNP data from N individuals who are an admixture of K unknown ancient populations. Let be the frequency of the reference allele of individual i at SNP s. So the number of reference alleles at SNP s for a diploid individual is binomially distributed with parameters 2 and . We suppose , where is the allele frequency of SNP s in population k and is the proportion of population k in the ancestry of individual i. I am interested in the identifiability of F and Q, up to a relabelling of the ancient populations. Under what conditions, when are and and and equal? I show that the anchor condition (Cabreros and Storey, 2019) on one matrix together with an independence condition on the other matrix is sufficient for identifiability. I will argue that the proof of the necessary condition in Cabreros and Storey, 2019 is incorrect, and I will provide a correct proof, which in addition does not require knowledge of the number of ancestral populations. I will also provide abstract necessary and sufficient conditions for identifiability. I will show that one cannot deviate substantially from the anchor condition without losing identifiability. Finally, I show necessary and sufficient conditions for identifiability for the non-admixed case.
Keywords
Cite
@article{arxiv.2202.05540,
title = {Necessary and sufficient conditions for identifiability in the admixture model},
author = {Jan van Waaij},
journal= {arXiv preprint arXiv:2202.05540},
year = {2022}
}