NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
Methodology
2024-07-11 v2 Applications
Abstract
Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.
Keywords
Cite
@article{arxiv.2302.12634,
title = {NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls},
author = {Pavla Krotka and Katharina Hees and Peter Jacko and Dominic Magirr and Martin Posch and Marta Bofill Roig},
journal= {arXiv preprint arXiv:2302.12634},
year = {2024}
}