Morphogen Gradient from a Noisy Source
Tissues and Organs
2007-05-23 v1 Other Condensed Matter
Molecular Networks
Other Quantitative Biology
Abstract
We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.
Keywords
Cite
@article{arxiv.q-bio/0502036,
title = {Morphogen Gradient from a Noisy Source},
author = {Jeremy L. England and John Cardy},
journal= {arXiv preprint arXiv:q-bio/0502036},
year = {2007}
}
Comments
Four pages, three figures