We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out.
Cite
@article{arxiv.1709.01431,
title = {Modeling specific action potentials in the human atria based on a minimal reaction-diffusion model},
author = {Yvonne Richter and Pedro G. Lind and Philipp Maass},
journal= {arXiv preprint arXiv:1709.01431},
year = {2018}
}