Physiological whole-body models are valuable tools for the development of novel drugs where understanding the system aspects is important. This paper presents a generalized model that encapsulates the structure and flow of whole-body human physiology. The model contains vascular, interstitial, and cellular subcompartments for each organ. Scaling of volumes and blood flows is described to allow for investigation across populations or specific patient groups. The model equations and the corresponding parameters are presented along with a catalog of functions that can be used to define the organ transport model and the biochemical reaction model. A simple example illustrates the procedure.
@article{arxiv.2404.14224,
title = {Modeling principles for a physiology-based whole-body model of human metabolism},
author = {Laura Hjort Blicher and Peter Emil Carstensen and Jacob Bendsen and Henrik Linden and Bjørn Hald and Kim Kristensen and John Bagterp Jørgensen},
journal= {arXiv preprint arXiv:2404.14224},
year = {2024}
}
Comments
6 pages, 3 figures, 3 tables, submitted to be presented at a conference