In this paper we use a simple toy model to explore the function of the gene Osteosarcoma-9. We are in particular interested in understanding the role of this gene as a potent anti-apoptotic factor. The theoretical description is constrained by experimental data from induction of apoptosis in cells where OS-9 is overexpressed. The data available suggest that OS-9 promotes cell viability and confers resistance to apoptosis, potentially implicating OS-9 in the survival of cancer cells. Three different apoptosis inducing mechanisms were tested and are here modelled. More complex and realistic models are also discussed.
@article{arxiv.q-bio/0608030,
title = {Model for Osteosarcoma-9 as a Potent Factor in Cell Survivor and Resistance to Apoptosis},
author = {Ekaterini Vourvouhaki and Carla Carvalho and Paulo Aguiar},
journal= {arXiv preprint arXiv:q-bio/0608030},
year = {2007}
}
Comments
24 pages, 16 pictures, version accepted for publication in PRE