MHC Restriction of V-V Interactions in Serum IgG
Abstract
According to Jerne's idiotypic network hypothesis, the adaptive immune system is regulated by interactions between the variable regions of antibodies, B cells, and T cells.1 The symmetrical immune network theory2,3 is based on Jerne's hypothesis, and provides a basis for understanding many of the phenomena of adaptive immunity. The theory includes the postulate that the repertoire of serum IgG molecules is regulated by T cells, with the result that IgG molecules express V region determinants that mimic V region determinants present on suppressor T cells. In this paper we describe rapid binding between purified murine serum IgG of H-2b and H-2d mice and serum IgG from the same strain and from MHC-matched mice, but not between serum IgG preparations of mice with different MHC genes. We interpret this surprising finding in terms of a model in which IgG molecules are selected to have both anti-anti-(self MHC class II) and anti-anti-anti-(self MHC class II) specificity.
Cite
@article{arxiv.1403.1551,
title = {MHC Restriction of V-V Interactions in Serum IgG},
author = {Earnest Leung and Geoffrey W. Hoffmann},
journal= {arXiv preprint arXiv:1403.1551},
year = {2014}
}