Metagenomic studies have primarily relied on de novo assembly for reconstructing genes and genomes from microbial mixtures. While reference-guided approaches have been employed in the assembly of single organisms, they have not been used in a metagenomic context. Here we describe the first effective approach for reference-guided metagenomic assembly that can complement and improve upon de novo metagenomic assembly methods for certain organisms. Such approaches will be increasingly useful as more genomes are sequenced and made publicly available.
@article{arxiv.2403.01578,
title = {MetaCompass: Reference-guided Assembly of Metagenomes},
author = {Tu Luan and Victoria Cepeda and Bo Liu and Zac Bowen and Ujjwal Ayyangar and Mathieu Almeida and Christopher M. Hill and Sergey Koren and Todd J. Treangen and Adam Porter and Mihai Pop},
journal= {arXiv preprint arXiv:2403.01578},
year = {2024}
}
Comments
18 pages, 6 figures, 3 tables, one supplementary material