Meta-Diastereomers Hierarchical Multiscale Chiral Interactions Between Biomolecules and Nanoscale Enantiomers
Abstract
We introduce meta-diastereomers, hybrid systems where molecular chirality (\,nm) and nanoscale chirality (\,nm) combine to create a new hierarchical chiral state with emergent optical properties. By coupling chiral biomolecules electrostatically with enantiomeric silicon nanostructures, we demonstrate how distinct chiral systems can interact to produce optical responses -- linear and circular dichroism -- that reflect the combined chirality of both components. This unique interplay of chirality across scales represents a conceptual advance in chiral nanophotonics. Importantly, we leverage the meta-diastereomers to probe a model antibody-antigen interaction, analogous to how molecular diastereomers are used in chemistry to investigate chiral structures. This work establishes a platform for label-free, highly specific detection of biomolecular interactions and opens new avenues for exploring hierarchical chirality in optics, biosensing, and quantum technologies.
Keywords
Cite
@article{arxiv.2508.05219,
title = {Meta-Diastereomers Hierarchical Multiscale Chiral Interactions Between Biomolecules and Nanoscale Enantiomers},
author = {Dominic J. P. Koyroytsaltis-McQuire and Rahul Kumar and Shailendra K. Chaubey and Tamas Javorfi and Giuliano Siligardi and Affar Karimullah Adrian J. Lapthorn and Nikolaj Gadegaard and Malcolm Kadodwala},
journal= {arXiv preprint arXiv:2508.05219},
year = {2025}
}