Brain tumours are masses of abnormal cells that can grow in an uncontrolled way in the brain. There are different types of malignant brain tumours. Gliomas are malignant brain tumours that grow from glial cells and are identified as astrocytoma, oligodendroglioma, and ependymoma. We study a mathematical model that describes glia-neuron interaction, glioma, and chemotherapeutic agent. In this work, we consider drug sensitive and resistant glioma cells. We show that continuous and pulsed chemotherapy can kill glioma cells with a minimal loss of neurons.
@article{arxiv.2012.08252,
title = {Mathematical model of brain tumour growth with drug resistance},
author = {José Trobia and Kun Tian and Antonio Marcos Batista and Celso Grebogi and Hai-Peng Ren and Moises Souza Santos and Paulo Ricardo Protachevicz and Fernando da Silva Borges and José Danilo Szezech and Ricardo Luiz Viana and Iberê Luiz Caldas and Kelly Cristiane Iarosz},
journal= {arXiv preprint arXiv:2012.08252},
year = {2021}
}