Magnesium is the most abundant intracellular divalent cation. We present an innovative experimental approach to localizing intracellular magnesium that combines elemental and morphological information from individual cells with high-resolution spatial information. Integration of information from scanning fluorescence X-ray microscopy with information from atomic force microscopy was used to generate a magnesium concentration map and to determine the X-ray linear absorption coefficient map within a whole dehydrated mammary epithelial cell.
@article{arxiv.1007.1744,
title = {Mapping cellular magnesium using X-ray microfluorescence and atomic force microscopy},
author = {Stefano Lagomarsino and Stefano Iotti and Giovanna Farruggia and Alessia Cedola and Valentina Trapani and Michela Fratini and Inna Bukreeva and Andrea Notargiacomo and Lucia Mastrototaro and Ian McNulty and Stefan Vogt and Daniel Legnini and Sangsoo Kim and Jeanette A M Maier and Federica I Wolf},
journal= {arXiv preprint arXiv:1007.1744},
year = {2010}
}