Magnetically modulated fluorescent probes in turbid media
Abstract
Magnetically modulated optical nanoprobes (MagMOONs) were used to detect and distinguish probe fluorescence from autofluorescent backgrounds in turbid media. MagMOONs are micro/nano-sized particles with magnetically controlled orientation and orientation-dependent fluorescence. These probes blink when they rotate in response to rotating external magnetic fields. This blinking signal can be separated from backgrounds enabling spectrochemical sensing in media with strong autofluorescence. We explore the effect of scattering on MagMOON fluorescence. Turbid media reduce the modulated MagMOON signal due to a combination of attenuation of fluorescence signal and reduction in contrast between "On" and "Off" states. The blinking MagMOON fluorescence spectrum can be detected in turbid non-dairy creamer solution with extinction 2.0, and through 9 mm of chicken breast tissue, suggesting that whole mouse imaging is feasible by using this strategy.
Keywords
Cite
@article{arxiv.1007.2863,
title = {Magnetically modulated fluorescent probes in turbid media},
author = {Yang and KhanhVan T. Nguyen and Hongyu Chen and Jeffrey N. Anker},
journal= {arXiv preprint arXiv:1007.2863},
year = {2010}
}
Comments
Paper presented at the 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Rostock Germany, May 25 2010